Entries by melina

Combined proteome and transcriptome analyses reveal that Zika virus circulating in Brazil alters cell cycle and neurogenic programmes in human neurospheres

May 16, 2016 /0 Comments/in /by

Combined proteomics and mRNA transcriptional profile analyses showed that Brazilian ZIKV, prior to induce cell death, alters cell cycle and halts neurogenic programmes, in addition to regulate transcription and protein translation due to viral replication. These results point to biological mechanisms potentially implicated in brain malformations as a result of ZIKV congenital infection. Read more […]

Combating Zika virus

May 11, 2016 /0 Comments/in /by

To stop the spread of Zika and prevent other infectious disease outbreaks,USAID launched Combating Zika and Future Threats: A Grand Challenge for Development. The challenge calls upon the global innovator community to generate cutting-edge approaches to fight the current Zika outbreak and to help strengthen the world’s response to infectious diseases in the future. Combating […]

Adding Zika Virus to the FDA Priority Review Voucher Program Act

May 11, 2016 /0 Comments/in /by

This bill amends the Federal Food, Drug, and Cosmetic Act to add the Zika virus to the list of tropical diseases under the priority review voucher program, which awards a voucher to the sponsor of a new drug or biological product that is approved to prevent or treat a tropical disease. (A voucher entitles the […]

Zika Virus Vaccine Programme

May 11, 2016 /0 Comments/in /by

A new Zika vaccine based on a simian adenoviral vector is being developed in Oxford to determine if it is immunogenic and can be taken to clinical trials. This development is part of a global rapid response programme. May 11, 2016 Zika Virus Vaccine Programme – Jenner Institute Read more

Zika virus animation

May 10, 2016 /0 Comments/in /by

The model of Zika virus is a part of the non-commercial educational project Viral Park, which was launched by the Visual Science in 2009. The project includes models of HIV, influenza A/H1N1, adenovirus, Ebola and papilloma viruses. Models and visualizations of the Viral Park received Science Magazine and National Science Foundation awards, appeared on the […]

The history of Zika virus

May 9, 2016 /0 Comments/in /by

A chronological map of the presence of Zika only in those countries for which there is evidence of indigenous transmission by mosquitos, excluding the many countries that have notified imported Zika. infections. The following timeline summarizes the spread of Zika infection, country by country, from the earliest discovery in 1947 to the latest information as […]

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

May 7, 2016 /0 Comments/in /by

Here we show that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number. The innate immune receptor Toll-like-Receptor 3 (TLR3) was upregulated after ZIKV infection of human organoids and mouse neurospheres and TLR3 inhibition reduced the phenotypic effects […]

Wolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes

May 5, 2016 /0 Comments/in /by

The recent association of Zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the Zika vector, Aedes aegyptimosquitoes. Wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. Here we report that Aedes aegypti harboringWolbachia are highly resistant to infection with two […]