nature17994-f2

Structure of the thermally stable Zika virus

Here we present the 3.7 Å resolution cryo-electron microscopy structure of ZIKV, and show that the overall architecture of the virus is similar to that of other flaviviruses. Sequence and structural comparisons of the ZIKV envelope (E) protein with other flaviviruses show that parts of the E protein closely resemble the neurovirulent West Nile and Japanese encephalitis viruses, while others are similar to dengue virus (DENV). However, the contribution of the E protein to flavivirus pathobiology is currently not understood. The virus particle was observed to be structurally stable even when incubated at 40 °C, in sharp contrast to the less thermally stable DENV. This is also reflected in the infectivity of ZIKV compared to DENV serotypes 2 and 4 (DENV2 and DENV4) at different temperatures. The cryo-electron microscopy structure shows a virus with a more compact surface. This structural stability of the virus may help it to survive in the harsh conditions of semen, saliva and urine. Antibodies or drugs that destabilize the structure may help to reduce the disease outcome or limit the spread of the virus.

nature17994-f2

Structure of the thermally stable Zika virus : Nature : Nature Publishing Group

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ns1

Zika virus NS1 crystallographic structure reveals diversity of electrostatic surfaces among flaviviruses

nejmsr1604338_t1

Zika Virus and Birth Defects — Reviewing the Evidence for Causality

On the basis of this review, we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies.

April 14, 2016

nejmsr1604338_t1

homolgy

Illustrating and homology modeling the proteins of the Zika virus

Several suggested steps have been proposed which could be taken to initiate ZIKV antiviral drug discovery using both high throughput screens as well as structure-based design based on homology models for the key proteins. We now describe preliminary homology models created for NS5, FtsJ, NS4B, NS4A, HELICc, DEXDc, peptidase S7, NS2B, NS2A, NS1, E stem, glycoprotein M, propeptide, capsid and glycoprotein E using SWISS-MODEL.

May 5, 2016

Illustrating and homology modeling the proteins of the Zika virus – F1000Research

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myelitis

Acute myelitis due to Zika virus infection

gb

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barré syndrome.

May 1, 2016

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Figure: Weekly cases of suspected Zika virus infections and Guillain-Barré syndrome in French Polynesia between October, 2013, and April, 2014
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The Zika Virus: What You Need to Know

Here are a few answers to some questions that many Americans may have about the Zika disease and who it could impact.
February 26, 2016

The Zika Virus: What You Need to Know | whitehouse.gov

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