Entries by melina

The spectrum of neuropathological changes associated with congenital Zika virus infection

A major concern associated with ZIKV infection is the increased incidence of microcephaly with frequent calcifications in infants born from infected mothers. To date, postmortem analysis of the central nervous system (CNS) in congenital infection is limited to individual reports or small series. We report a comprehensive neuropathological study in ten newborn babies infected with […]

Zika Virus Infection and Solid Organ Transplantation: A New Challenge

Public health concerns exist surrounding the epidemic of the Zika virus (ZIKV) and the rapid growth of transplantation in developing countries, including endemic zones of active arbovirus transmission, as well as travel to such regions by potential organ donors and recipients. Few data exist regarding the clinical characteristics of ZIKV infection in immunocompromised hosts. Laboratory […]

Zika virus causes testicular atrophy

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has recently been found to cause fetal infection and neonatal abnormalities, including microcephaly and neurological dysfunction. ZIKV persists in the semen months after the acute viremic phase in humans. To further understand the consequences of ZIKV persistence in males, we infected Ifnar1−/− mice via subcutaneous injection […]

Genome sequencing reveals Zika virus diversity and spread in the Americas

Despite great attention given to the recent Zika virus (ZIKV) epidemic in the Americas, much remains unknown about its epidemiology and evolution, in part due to a lack of genomic data. We applied multiple sequencing approaches to generate 100 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed […]

Potential use of saliva samples to diagnose Zika virus infection

Serological diagnosis of ZIKV in countries where dengue virus (DENV) is endemic is challenging, because antibodies elicited by a prior DENV infection may cross-react against ZIKV. Therefore, molecular techniques, such as conventional or real-time reverse transcriptase polymerase chain reaction (RT-PCR/qRT-PCR), remain the reference methods for the diagnosis of ZIKV. However, the sensitivity of ZIKV RT-PCR […]

Mathematical model for Zika virus dynamics with sexual transmission route

Zika virus is a flavivirus transmitted to humans primarily through the bite of infected Aedes mosquitoes. In addition to vector-borne spread, however, the virus can also be transmitted through sexual contact. In this paper, we formulate and analyze a new system of ordinary differential equations which incorporates both vector and sexual transmission routes. Theoretical analysis […]