Entries by melina

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly

Phylogenetic analysis reveals that contemporary epidemic strains have accumulated multiple substitutions from their Asian ancestor. Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality […]

Zika virus replication in the mosquito Culex quinquefasciatus in Brazil

Zika virus (ZIKV) is a flavivirus that has recently been associated with an increased incidence of neonatal microcephaly and other neurological disorders. The virus is primarily transmitted by mosquito bite, although other routes of infection have been implicated in some cases. The Aedes aegypti mosquito is considered to be the main vector to humans worldwide; […]

UFG descobre novos compostos que podem ajudar a tratar pessoas com zika

A Universidade Federal de Goiás (UFG) descobriu novos compostos que podem ajudar no tratamento de pessoas com o vírus da zika. Ao todo, nove substâncias foram selecionadas para testes em células infectadas, que serão feitos em uma universidade dos Estados Unidos. O objetivo é desenvolver medicamentos para combater a doença. Leia mais

UFG descobre novos possíveis compostos contra o vírus Zika

Em maio de 2016, a Universidade Federal de Goiás (UFG), em parceria com a World Community Grid (WCG), da International Business Machines (IBM), iniciou o projeto OpenZika, que visa identificar substâncias com potencial para tratar pessoas infectadas pelo vírus Zika. De uma lista inicial de aproximadamente 7.600 compostos, dentre eles fármacos já aprovados para uso […]

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug […]

The spectrum of neuropathological changes associated with congenital Zika virus infection

A major concern associated with ZIKV infection is the increased incidence of microcephaly with frequent calcifications in infants born from infected mothers. To date, postmortem analysis of the central nervous system (CNS) in congenital infection is limited to individual reports or small series. We report a comprehensive neuropathological study in ten newborn babies infected with […]

Zika Virus Infection and Solid Organ Transplantation: A New Challenge

Public health concerns exist surrounding the epidemic of the Zika virus (ZIKV) and the rapid growth of transplantation in developing countries, including endemic zones of active arbovirus transmission, as well as travel to such regions by potential organ donors and recipients. Few data exist regarding the clinical characteristics of ZIKV infection in immunocompromised hosts. Laboratory […]