Entries by melina

Fiocruz descobre que pernilongo pode transmitir zika

Os resultados foram publicados hoje (9) na revista Emerging microbes & infections, do grupo Nature. O artigo é intitulado “Zika virus replication in the mosquito Culex quinquefasciatus in Brazil” e pode ser encontrado na íntegra na internet. Os mosquitos do gênero Culex foram colhidos na Região Metropolitana do Recife, já infectados. A equipe do Departamento […]

Por que os casos de zika e dengue estão despencando no Brasil

“Vemos epidemias de dengue há cerca de 30 anos e ficamos refratários a ouvir falar sobre a doença. Com o zika, realmente saímos da zona de conforto, ficou clara a importância do controle doméstico do mosquito, e acredito que houve uma reação mais forte do poder público e da esfera privada” Denise Valle Instituto Oswaldo […]

UFG descobre novos possíveis compostos contra o vírus Zika

Em maio de 2016, a Universidade Federal de Goiás (UFG), em parceria com a World Community Grid (WCG), da International Business Machines (IBM), iniciou o projeto OpenZika, que visa identificar substâncias com potencial para tratar pessoas infectadas pelo vírus Zika. De uma lista inicial de aproximadamente 7.600 compostos, dentre eles fármacos já aprovados para uso […]

Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase

The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug […]

Molecular dynamics simulations of Zika virus NS3 helicase: Insights into RNA binding site activity

America is still suffering with the outbreak of Zika virus (ZIKV) infection. Congenital ZIKV syndrome has already caused a public health emergency of international concern. However, there are still no vaccines to prevent or drugs to treat the infection caused by ZIKV. The ZIKV NS3 helicase (NS3h) protein is a promising target for drug discovery […]

The spectrum of neuropathological changes associated with congenital Zika virus infection

A major concern associated with ZIKV infection is the increased incidence of microcephaly with frequent calcifications in infants born from infected mothers. To date, postmortem analysis of the central nervous system (CNS) in congenital infection is limited to individual reports or small series. We report a comprehensive neuropathological study in ten newborn babies infected with […]