Entries by melina

Illustrating and homology modeling the proteins of the Zika virus

Several suggested steps have been proposed which could be taken to initiate ZIKV antiviral drug discovery using both high throughput screens as well as structure-based design based on homology models for the key proteins. We now describe preliminary homology models created for NS5, FtsJ, NS4B, NS4A, HELICc, DEXDc, peptidase S7, NS2B, NS2A, NS1, E stem, […]

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barré syndrome. May 1, 2016 Figure: Weekly cases of suspected Zika virus infections and Guillain-Barré syndrome […]

Uganda: Por que o berço do zika nunca teve nenhum surto?

O que explica então a ausência de um surto de zika no país africano? Segundo Julius Lutwama, principal virologista do Instituto de Uganda de Pesquisa de Vírus (Urvi, na sigla em inglês), o motivo se deve, em grande parte, ao tipo de Aedes aegypti encontrado em Uganda. “Em Uganda, a subespécie de Aedes aegypti que […]

Open drug discovery for the Zika virus

We provide some suggestions of what might be possible and propose an open drug discovery effort that mobilizes global science efforts and provides leadership, which thus far has been lacking. We also provide a listing of potential resources and molecules that could be prioritized for testing as in vitro assays for ZIKV are developed. We propose also […]