Entries by melina

Zika, colaboração para caracterizar uma síndrome

No fim de 2016, consolidou-se a ideia de que a microcefalia representa apenas uma fração dos problemas provocados pelo vírus zika – possivelmente a menor, mas a mais trágica por suas consequências permanentes. Trabalhos publicados em dezembro e nos meses anteriores passaram a caracterizar com mais detalhe o amplo espectro de danos que o bebê […]

Mathematical model for Zika virus dynamics with sexual transmission route

Zika virus is a flavivirus transmitted to humans primarily through the bite of infected Aedes mosquitoes. In addition to vector-borne spread, however, the virus can also be transmitted through sexual contact. In this paper, we formulate and analyze a new system of ordinary differential equations which incorporates both vector and sexual transmission routes. Theoretical analysis […]

Vulnerability of primitive human placental trophoblast to Zika virus

Infection of pregnant women by Asian lineage strains of Zika virus (ZIKV) has been linked to brain abnormalities in their infants, yet it is uncertain when during pregnancy the human conceptus is most vulnerable to the virus. We have examined two models to study susceptibility of human placental trophoblast to ZIKV: cytotrophoblast and syncytiotrophoblast derived […]

Zika pode causar cegueira em bebês

Médicos da Universidade Federal de São Paulo (Unifesp) e da Fundação Altino Ventura de Pernambuco descobriram que a microcefalia associada ao zika vírus pode ser a causa de uma lesão na mácula ocular diferente daquelas causadas por outros tipos de microcefalia. “É uma lesão irreversível na visão. Dependendo do lugar da retina e da intensidade, […]

Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in fission yeast

The Zika virus (ZIKV) causes various neurologic defects including microcephaly and the Guillain-Barré syndrome. However, little is known about how ZIKV causes those diseases or which viral protein(s) is responsible for the observed cytopathic effects involved in restricted neuronal cellular growth, dysregulation of the cell cycle, and induction of cell hypertrophy or cell death. A […]

Researchers identify key proteins that may make Zika so deadly

Until it burst onto the scene earlier this year, Zika was an obscure, little-known virus. As a result, scientists know little about how it works. Over the past year, they have learned that it can cause a range of dangerous health problems, including birth defects such as microcephaly and neurological problems such as Guillain-Barré syndrome. […]

Structure of the immature Zika virus at 9 Å resolution

The current Zika virus (ZIKV) epidemic is characterized by severe pathogenicity in both children and adults. Sequence changes in ZIKV since its first isolation are apparent when pre-epidemic strains are compared with those causing the current epidemic. However, the residues that are responsible for ZIKV pathogenicity are largely unknown. Here we report the cryo-electron microscopy […]

Fifth meeting of the Emergency Committee under the International Health Regulations (2005) regarding microcephaly, other neurological disorders and Zika virus

The Public Health Emergency of International Concern (PHEIC) declared by the Director-General of WHO has led the world to an urgent and coordinated response, providing the understanding that Zika virus infection and associated consequences represent a highly significant long-term problem that must be managed by WHO, States Parties and other partners in a way that […]

Estudo mostra casos de bebês infectados com zika que desenvolveram microcefalia após o nascimento

Alguns bebês infectados pelo vírus da zika nascem aparentemente saudáveis, mas têm malformações cerebrais e depois desenvolvem a microcefalia, um crescimento da cabeça abaixo da média, segundo um estudo divulgado na terça-feira (22). Os Centros de Controle e Prevenção das Doenças dos Estados Unidos (CDC, na sigla em inglês) publicaram um estudo que descreve 13 […]