Entries by melina

Illustrating and homology modeling the proteins of the Zika virus

Several suggested steps have been proposed which could be taken to initiate ZIKV antiviral drug discovery using both high throughput screens as well as structure-based design based on homology models for the key proteins. We now describe preliminary homology models created for NS5, FtsJ, NS4B, NS4A, HELICc, DEXDc, peptidase S7, NS2B, NS2A, NS1, E stem, […]

Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study

This is the first study providing evidence for Zika virus infection causing Guillain-Barré syndrome. Because Zika virus is spreading rapidly across the Americas, at risk countries need to prepare for adequate intensive care beds capacity to manage patients with Guillain-Barré syndrome. May 1, 2016 Figure: Weekly cases of suspected Zika virus infections and Guillain-Barré syndrome […]

Zika virus: Inside Uganda’s forest where the disease originates

Only two cases of the virus have been confirmed in Uganda in the past seven decades. This is because the types of mosquitoes that would transmit the virus to humans don’t often come into contact with the general population, says Dr Julius Lutwama, a leading virologist at the Uganda Virus Research Institute. “The Aedes we […]

Open drug discovery for the Zika virus

We provide some suggestions of what might be possible and propose an open drug discovery effort that mobilizes global science efforts and provides leadership, which thus far has been lacking. We also provide a listing of potential resources and molecules that could be prioritized for testing as in vitro assays for ZIKV are developed. We propose also […]