Vírus da Zika é encontrado em saguis e macacos-prego no interior do Ceará

Pela primeira vez, pesquisadores encontraram fora do continente africano, no Ceará, primatas infectados com o vírus da zika, transmitido pelo mosquito Aedes aegypti. De acordo com os pesquisadores, a descoberta indica que, por ser capaz de contaminar outros hospedeiros além dos humanos, a doença se espalha com mais facilidade e, consequentemente, pode dificultar o controle.

22 de abril de 2016



G1 – Vírus da zika é encontrado em saguis e macacos-prego no interior do Ceará – notícias em Ceará

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Structure of the thermally stable Zika virus

Here we present the 3.7 Å resolution cryo-electron microscopy structure of ZIKV, and show that the overall architecture of the virus is similar to that of other flaviviruses. Sequence and structural comparisons of the ZIKV envelope (E) protein with other flaviviruses show that parts of the E protein closely resemble the neurovirulent West Nile and Japanese encephalitis viruses, while others are similar to dengue virus (DENV). However, the contribution of the E protein to flavivirus pathobiology is currently not understood. The virus particle was observed to be structurally stable even when incubated at 40 °C, in sharp contrast to the less thermally stable DENV. This is also reflected in the infectivity of ZIKV compared to DENV serotypes 2 and 4 (DENV2 and DENV4) at different temperatures. The cryo-electron microscopy structure shows a virus with a more compact surface. This structural stability of the virus may help it to survive in the harsh conditions of semen, saliva and urine. Antibodies or drugs that destabilize the structure may help to reduce the disease outcome or limit the spread of the virus.


Structure of the thermally stable Zika virus : Nature : Nature Publishing Group

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Zika virus NS1 crystallographic structure reveals diversity of electrostatic surfaces among flaviviruses


Zika Virus and Birth Defects — Reviewing the Evidence for Causality

On the basis of this review, we conclude that a causal relationship exists between prenatal Zika virus infection and microcephaly and other serious brain anomalies.

April 14, 2016



Fiocruz promove seminários discutindo controle, atenção e vigilância dos vírus Zika, Dengue e Chikungunya